Miniaturization of cantilevers for atomic force microscopy has increased their resonant frequencies and decreased their thermal noise, allowing faster, lower noise measurements. When used in the extremely low-noise Cypher AFM, these levers have enabled significant improvements in imaging resolution in air and especially in liquids. On crystals, individual atomic point defects can now be routinely resolved and this higher resolution also extends to biological samples. Examples shown include the movement of individual point defects in bacteriorhodopsin, atomic point defects in calcite, and resolution of the double-helix structure of DNA in solution.
Dr. Jason Cleveland is CEO and co-founder of Asylum Research, an Oxford Instruments company. He has over 20 years of AFM experience. He has co-authored many papers and is a co-inventor on numerous AFM patents. He received his Ph.D. from the University of California Santa Barbara.